
Reconstruction of a mammoth at the Royal BC Museum in Victoria, Canada.
In reaching synthesize hemoglobin mammoth DNA from fossil An international team has shown that the of these prehistoric pachyderms managed to carry oxygen even at low temperatures.
This is not Jurassic Park, but it'sa start. An international team of researchers has indeed succeeded in recreating the true of mammoth from DNA found in old bones of this extinct there over 10,000 years. An epic experimental over seven years to better understand how this mythical animal had adapted to winters prehistoric Siberian and North America. His did not need to be very hot to fulfill its primary mission: to bring oxygen to the organs.
The idea, a little crazy, to resurrect the mammoth hemoglobin is to the credit of Professor Campbell, a biologist at the University of Adelaide, Australia, and lead author of This study published Monday in the journal Nature Genetics. How do researchers have conducted? He first had to get out of bone, well preserved in ice for over 20,000 years, DNA in good condition. Then, identify the site responsible for the synthesis of hemoglobin and into RNA (the alter ego of the DNA that allows the effective synthesis of proteins). Then the scientists injected this RNA into a bacterium called Escherichia coli, which has been naturally synthesize the protein corresponding to the strand of RNA which had been introduced (this technique, known, is already used to produce the human insulin).
A mammoth cloned in 2050?
Each of these steps represented a major scientific challenge. The collaboration of seven countries has also been necessary to carry out this work (Australia, Canada, Japan, USA, Germany, England and Denmark). But this painstaking work paid off. For this hemoglobin "prehistoric" reveals astonishing physiological characteristics at the imposing elephant.
It would appear that the temperature of the mammoth had a material impact on the exchange of oxygen. This may not seem like much, but it is fundamental. For a human being or an elephant, hemoglobin can to properly exchange of oxygen at temperatures high enough. When body temperature drops, the distribution of oxygen in the body becomes more difficult. Our bodies must constantly be maintained at a temperature high enough that these exchanges are correct. It seems that this was not the case with the mammoth that seems perfectly suited to harsh conditions of the Arctic.
To confirm this finding, it remains to wait until scientists are raised, by cloning, a real mammoth. This is not necessarily science fiction. Since 2002, the Japanese are working hard on this project which should however not be completed before 2050.
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